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Double Resonance Techniques: Overview

Double Resonance Techniques: Overview

Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...

Spin–Spin Coupling Constant: Overview

Spin–Spin Coupling Constant: Overview

In bromoethane, the three methyl protons are coupled to the two methylene protons that are three bonds away. In accordance with the n+1 rule, the signal from the methyl protons is split into three peaks with 1:2:1 relative intensities. The methylene protons appear as a quartet, with the relative intensities of 1:3:3:1.
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must have a...

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)

Two NMR-active nuclei bonded to a central atom can be involved in geminal or two-bond coupling. Geminal coupling is commonly seen between diastereotopic protons in chiral molecules and unsymmetrical alkenes, among others.
The central atom need not be NMR-active because its electrons are affected by the electron polarization of the spin-active atoms. However, spin information is transmitted less effectively than in one-bond coupling, and 2J values are usually weaker than 1J values. The energy of...

Magnetic Field Due to Two Straight Wires

Magnetic Field Due to Two Straight Wires

Consider two parallel straight wires carrying a current of 10 A and 20 A in the same direction and separated by a distance of 20 cm. Calculate the magnetic field at a point "P2", midway between the wires. Also, evaluate the magnetic field when the direction of the current is reversed in the second wire.

Spin–Spin Coupling: One-Bond Coupling

Spin–Spin Coupling: One-Bond Coupling

Coupling interactions are strongest between NMR-active nuclei bonded to each other, where spin information can be transmitted directly through the pair of bonding electrons. While nuclei polarize their electrons to the opposite spins, the bonding electron pair has opposite spins. Configurations with antiparallel nuclear spins are expected to be lower in energy. When coupling makes antiparallel states more favorable, J is considered to have a positive value. The one-bond coupling constant, 1J,...

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

Vicinal or three-bond coupling is commonly observed between protons attached to adjacent carbons. Here, nuclear spin information is primarily transferred via electron spin interactions between adjacent C‑H bond orbitals. This generally favors the antiparallel arrangement of spins, so 3J values are usually positive.
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the involved orbitals. The...

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Updated: Jun 18, 2026

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning

Magnetic Resonance Spectroscopy of live Drosophila melanogaster using Magic Angle Spinning

Published on: April 15, 2010

Double-resonance magic angle coil spinning.

Munehiro Inukai¹, Kazuyuki Takeda

¹Division of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo, 606-8502 Kyoto, Japan.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)

|November 21, 2009

Summary

This summary is machine-generated.

We extended magic angle coil spinning (MACS) solid-state NMR to double-resonance experiments. This allows advanced techniques like cross-polarization and 2D correlation spectroscopy with MACS benefits.

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Area of Science:

Solid-state Nuclear Magnetic Resonance (NMR) Spectroscopy
Advanced Spectroscopic Techniques

Background:

Magic Angle Coil Spinning (MACS) offers advantages like high concentration sensitivity and reduced magnetic susceptibility.
Implementing double-resonance experiments in solid-state NMR is crucial for detailed molecular structure analysis.

Purpose of the Study:

To extend Magic Angle Coil Spinning (MACS) solid-state NMR spectroscopy to accommodate double-resonance experiments.
To integrate powerful double-resonance NMR methodologies within the MACS framework.

Main Methods:

Adaptation of Magic Angle Coil Spinning (MACS) techniques for double-resonance solid-state NMR.
Implementation of cross-polarization and proton decoupling protocols.
Development of two-dimensional (2D) correlation spectroscopy within the MACS setup.

Main Results:

Successful extension of MACS to enable double-resonance solid-state NMR experiments.
Preservation of intrinsic MACS benefits, including high concentration sensitivity.
Elimination of magnetic susceptibility-induced field distortions.
Demonstration of an accessible approach using conventional hardware.

Conclusions:

The presented extension broadens the applicability of MACS solid-state NMR.
This advancement facilitates advanced structural investigations using readily available equipment.
The method combines the advantages of MACS with the power of double-resonance NMR techniques.