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Related Experiment Videos

Recurrent acute glomerulonephritis.

D Glotz1, M H Jouvin, D Nochy

  • 1Service de Néphrologie et INSERM Unité 28, Hôpital Broussais, Paris, France.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|February 1, 1991
PubMed
Summary
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Recurrent acute glomerulonephritis (AGN) is rare, especially in adults without chronic infections. This case highlights elderly patients experiencing repeated AGN episodes linked to respiratory infections.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathology

Background:

  • Recurrent acute glomerulonephritis (AGN) is typically observed in pediatric patients following streptococcal infections.
  • The occurrence of recurrent AGN in elderly individuals without evident chronic bacterial infection is exceptionally uncommon.

Observation:

  • An 80-year-old male experienced eight distinct episodes of acute nephritic syndrome.
  • These episodes consistently followed upper respiratory tract infections.
  • Renal biopsies during acute phases revealed characteristic postinfectious acute exsudative endocapillary glomerulonephritis.

Findings:

  • Biopsy-proven recurrent acute glomerulonephritis was diagnosed in an 80-year-old man.
  • The patient had no underlying chronic bacterial infection.

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  • Episodes correlated with upper respiratory tract infections, with normal renal histology during remission.

    • Implications:

    • This case expands the known clinical spectrum of recurrent AGN, suggesting a potential link to common infections in the elderly.
    • It underscores the importance of considering postinfectious glomerulonephritis in older adults presenting with recurrent nephritic syndrome, even without typical triggers.
    • Further research may be warranted to explore the immunological mechanisms underlying recurrent AGN in the absence of chronic infections.