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Apoptosis by dietary agents for prevention and treatment of prostate cancer

Naghma Khan1, Vaqar Mustafa Adhami, Hasan Mukhtar

  • 1Department of Dermatology, Medical Sciences Center, University of Wisconsin-Madison, 4385, 1300 University Avenue, Madison, Wisconsin 53706, USA.

Endocrine-Related Cancer
|November 21, 2009
PubMed

Insights

Dietary compounds that induce apoptosis, programmed cell death, show promise for cancer chemoprevention. Studies explore these agents for prostate cancer (PCa) prevention, examining their effects in cell cultures, animals, and human trials.

Area of Science:

  • Oncology
  • Cell Biology
  • Nutritional Science

Background:

  • Apoptosis, or programmed cell death, is crucial for cancer chemoprevention by dietary agents.
  • Mammalian cells utilize extrinsic and intrinsic pathways to regulate apoptosis.
  • Prostate cancer (PCa) is an ideal model for chemoprevention research due to its characteristics.

Purpose of the Study:

  • To review dietary compounds that induce apoptosis for prostate cancer (PCa) prevention.
  • To highlight research across in vitro, preclinical, and clinical trial settings.

Main Methods:

  • Review of scientific literature on apoptosis-inducing dietary compounds.
  • Analysis of studies investigating chemoprevention of prostate cancer (PCa).
  • Inclusion of in vitro, animal, and human clinical trial data.

Main Results:

  • Apoptosis induction by dietary agents is a key mechanism in cancer chemoprevention.
  • Various dietary compounds demonstrate potential for PCa prevention.
  • Evidence spans from cell culture to human clinical trials.

Conclusions:

  • Dietary compounds that trigger apoptosis are significant for cancer chemoprevention strategies.
  • Further research into these agents may lead to effective prostate cancer (PCa) prevention methods.

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