Related Experiment Video
Updated: Jun 18, 2026
Tricolor Transgenic Murine Model for Studying Growth Plate Injury
Published on: September 6, 2024
Advances in growth plate modulation for lower extremity malalignment (knock knees and bow legs)
Vladimir Goldman1, Daniel W Green
1Hospital for Special Surgery, New York, New York, USA.
Purpose Of Review:
Lower extremity angular deformities are among the most common nontraumatic conditions in children being referred to pediatric orthopedists. Understanding of this abnormality is essential for pediatricians and primary caregivers. There is a development in the surgical management of these problems that has improved the quality of care of affected children and adolescents.
Recent Findings:
In recent years, we have improved our understanding of consequences of lower limb angular deformities on knees. New treatment options for angular deformity include the method of 'guided growth' using small, extraphyseal tension band plates.
Summary:
The development of this surgical technique for growth plate manipulation for the treatment of angular deformities of knees has expanded the indications for surgical management and has a potential to decrease the incidence and the severity of complications.
Related Concept Videos
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:16Bones of the Lower Limb: Femur and Patella
01:27Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
01:07Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...