Related Experiment Video
Updated: Jun 18, 2026
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
Published on: November 20, 2009
A tribute to Dr. David Kline: a new approach to an old peripheral nerve problem--splicing instead of regenerating
Wesley Chang1, David Sretevan, Michel Kliot
1Departments of Ophthalmology and Physiology, Neuroscience Program and Bioengineering Program, University of California, San Francisco, San Francisco, California, USA.
Objective:
Our goal is to develop a novel method to repair damaged axons. This method relies on acutely restoring axonal continuity rather than the traditional approach of promoting axonal regeneration.
Methods:
Micro- and nanoechnological methods, in combination with focal application of electrical fields, are applied to individual and groups of axons both in vitro and in vivo.
Results:
Application of these techniques has permitted micromanipulation of axons at the cellular level and fusion of axonal membranes.
Conclusion:
Although a great deal more work is necessary, our findings suggest that it may one day be possible to repair acutely disrupted axons by splicing their membranes back together.
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