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Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Related Experiment Video

Updated: Jun 18, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

[Executive function in patients with late onset depression].

R Osorio1, B García de Lózar, I Ramos

  • 1Instituto de Salud Carlos III, Unidad de Investigación Proyecto Alzheimer, Valderreboyo, 5, 28031 Madrid, Spain. rosorio@fundacioncien.es

Actas Espanolas De Psiquiatria
|November 21, 2009
PubMed
Summary
This summary is machine-generated.

Late-onset depression in older adults is linked to significant executive function difficulties. This executive dysfunction may serve as a biological marker for late-life depression.

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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

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Last Updated: Jun 18, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Area of Science:

  • Geriatric Psychiatry
  • Neuropsychology
  • Cognitive Science

Context:

  • Late-onset depression is the most common psychiatric disorder in the elderly.
  • It is often associated with cognitive impairment and cardiovascular risk factors.
  • Late-onset depression may represent a distinct entity from adult depression.

Purpose:

  • To compare cognitive performance in neuropsychological screening tests.
  • To analyze executive functions in older adults with and without late-life depression.

Summary:

  • This study analyzed data from 20 older adults with late-life depression and 10 controls.
  • Standardized tests measured cognitive functions, executive performance, and depressive symptoms.
  • Late-onset depression patients exhibited significantly greater executive difficulties compared to controls.

Impact:

  • Executive dysfunction is identified as a potential biological marker for late-life depression.
  • Findings suggest a need for larger studies to confirm executive dysfunction as a marker.
  • This research contributes to understanding the cognitive profile of late-life depression.