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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

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Animal Models of Depression - Chronic Despair Model (CDM)
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Published on: September 23, 2021

[Circadian rhythms and depression].

V Soria1, M Urretavizcaya

  • 1Unidad Clínica y de Investigación en Trastornos Afectivos, Servicio de Psiquiatría, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Actas Espanolas De Psiquiatria
|November 21, 2009
PubMed
Summary
This summary is machine-generated.

Major depression is linked to circadian rhythm disturbances, affecting sleep and body temperature. Targeting the circadian system offers a promising therapeutic avenue for depression treatment.

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
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Published on: April 26, 2024

Area of Science:

  • Chronobiology
  • Neuroscience
  • Psychiatry

Context:

  • Major depression is associated with disruptions in daily biological rhythms.
  • Abnormalities in circadian rhythms of core body temperature and endocrine-metabolic parameters are observed in depressed individuals.
  • The sleep-wake cycle is intimately linked to circadian system functioning and is often disturbed in depression.

Purpose:

  • To review biological and clinical data connecting major depression with circadian rhythm abnormalities.
  • To explore the underlying mechanisms of circadian rhythm dysregulation in depressive states.
  • To examine therapeutic strategies for depression that leverage the circadian system.

Summary:

  • Core symptoms of major depression often exhibit circadian patterns.
  • Depressive patients show altered circadian rhythms compared to healthy controls.
  • Chronobiological treatments for depression demonstrate efficacy and rapid action, highlighting the circadian system as a therapeutic target.

Impact:

  • Establishes the circadian system as a key factor in major depression.
  • Provides insights into the pathophysiology of depression.
  • Supports the development of novel chronotherapy approaches for depression treatment.