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Related Concept Videos

Protein Folding01:22

Protein Folding

Overview
Protein Folding01:22

Protein Folding

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Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
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Protein and Protein Structure02:15

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Related Experiment Video

Updated: Jun 18, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

MUFOLD: A new solution for protein 3D structure prediction.

Jingfen Zhang1, Qingguo Wang, Bogdan Barz

  • 1Department of Computer Science, University of Missouri, Columbia, Missouri 65211, USA.

Proteins
|November 21, 2009
PubMed
Summary
This summary is machine-generated.

Researchers developed MUFOLD, a novel software package for protein structure prediction. This tool offers accurate and efficient protein modeling, significantly improving upon previous methods and demonstrating success in community-wide experiments.

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Last Updated: Jun 18, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
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Published on: July 25, 2013

Area of Science:

  • Computational biology
  • Structural bioinformatics
  • Biophysics

Background:

  • Protein structure prediction remains a challenge, with current computational methods lacking accuracy and accessibility for general users.
  • Despite advances, achieving precise protein structural models requires significant computational resources.

Purpose of the Study:

  • To develop a more accurate and efficient protein structure prediction software package.
  • To integrate novel methods for improved protein modeling capabilities.

Main Methods:

  • Developed a systematic protocol for identifying protein templates and fragments.
  • Employed iterative coarse-grain model generation and evaluation using spatial restraints and clustering.
  • Utilized molecular dynamics simulations for full-atom model assessment.

Main Results:

  • Achieved an average root-mean-square deviation of 4.28 Å for best models against native structures on a benchmark set.
  • Demonstrated significantly improved performance compared to previous methods.
  • Showcased reduced computing time compared to other protein structure prediction tools like Rosetta.

Conclusions:

  • MUFOLD represents a significant advancement in protein structure prediction accuracy and efficiency.
  • The software package shows promise for broader accessibility in structural bioinformatics.
  • MUFOLD performed successfully in the CASP8 protein structure prediction experiment.