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Isolation, Characterization, and Differentiation of Cardiac Stem Cells from the Adult Mouse Heart
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[Association between the number of peripheral blood stem cells and cardiac function index in patients with ischemic

Yu-ping Zhou1, Yuan-hui Hu, Hua-qin Wu

  • 1Department of Cardiology, Guang' an' men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|November 26, 2009
PubMed

Insights

Peripheral blood stem cell (PBSC) counts are linked to cardiac function in ischemic heart failure (IHF) patients. Lower PBSC numbers correlate with poorer heart function, indicating potential as a biomarker.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Context:

  • Ischemic heart failure (IHF) presents a significant clinical challenge.
  • Assessing cardiac function and identifying prognostic markers in IHF is crucial.
  • Peripheral blood stem cells (PBSC) are increasingly recognized for their role in tissue repair.

Purpose:

  • To investigate the association between peripheral blood stem cell (PBSC) count and cardiac function indices in patients with ischemic heart failure (IHF).
  • To determine if PBSC levels correlate with clinical parameters such as NYHA grade, left ventricular ejection fraction (LVEF), and N-terminal-proB-type Natriuretic Peptide (NT-proBNP).

Summary:

  • A study of 199 IHF patients found that lower PBSC counts were associated with higher NYHA grades.
  • Left ventricular ejection fraction (LVEF) showed a positive correlation with PBSC count (r = 0.35, P = 0.001).
  • N-terminal-proB-type Natriuretic Peptide (NT-proBNP) exhibited a negative correlation with PBSC count (r = -0.39, P = 0.009).

Impact:

  • PBSC count may serve as a novel biomarker for assessing cardiac function in IHF.
  • Findings suggest a potential link between stem cell levels and disease severity in IHF.
  • This research opens avenues for exploring stem cell-based therapies or prognostication in IHF.
Abstract

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