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Updated: Jun 18, 2026

Identification of Nucleolar Factors During HIV-1 Replication Through Rev Immunoprecipitation and Mass Spectrometry
Published on: June 26, 2019
[Accessory proteins of HIV and innate anti-retroviral factors]
Masako Nomaguchi1, Akio Adachi
1Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto, Tokushima 770-8503, Japan.
Abstract:
The HIV genome encodes several accessory proteins (Vif, Vpr, Vpx, Vpu, and Nef) unique to primate lentiviruses, in addition to the structural (Gag, Pol, and Env) and regulatory (Tat and Rev) proteins. Early studies showed that deletion of accessory proteins has a small or no effect on virus replication in cell cultures. However, recent studies have clearly demonstrated that these proteins are essential for efficient viral replication, dissemination, pathogenicity, and disease progression. Here, we summarize the current knowledge of HIV accessory proteins and their cellular targets, and discuss the functional roles of these biologically unique and important viral proteins for virus replication in vitro and in vivo.
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