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Central nervous system histamine regulates peripheral sympathetic activity.

V F Akins1, S L Bealer

  • 1Department of Physiology, University of Tennessee, Memphis 38163.

The American Journal of Physiology
|January 1, 1991
PubMed
Summary

Brain histamine plays a role in sympathetic activation. Depleting histamine in rats reduced pressor responses to hypertonic saline, indicating histamine

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Area of Science:

  • Neuroscience
  • Physiology
  • Pharmacology

Background:

  • Brain histamine (HA) influences various physiological processes.
  • The role of central histamine in cardiovascular regulation and sympathetic responses to osmotic stimuli is not fully understood.

Purpose of the Study:

  • To investigate the involvement of central brain histamine in the cardiovascular and sympathetic responses to hypertonic saline infusion in conscious rats.

Main Methods:

  • Conscious Sprague-Dawley rats were used.
  • Brain histamine was depleted using alpha-fluoromethyl-histidine (alpha-FMH).
  • Hypertonic saline was infused intravenously, and mean arterial pressure (MAP), heart rate (HR), plasma vasopressin (AVP), and norepinephrine (NE) were monitored.

Main Results:

  • Histamine depletion (alpha-FMH) or H1-antagonist (pyrilamine) pretreatment delayed and attenuated the pressor response and bradycardia to hypertonic saline.
  • Both treatments significantly reduced plasma norepinephrine levels.
  • Plasma vasopressin levels were unaffected by histamine depletion.

Conclusions:

  • Central histamine is involved in peripheral sympathetic activation during hypertonic saline infusion.
  • Brain histamine does not mediate vasopressin release in response to hyperosmotic stimuli.

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