Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Calibration Curves: Linear Least Squares01:20

Calibration Curves: Linear Least Squares

A calibration curve is a plot of the instrument's response against a series of known concentrations of a substance. This curve is used to set the instrument response levels, using the substance and its concentrations as standards. Alternatively, or additionally, an equation is fitted to the calibration curve plot and subsequently used to calculate the unknown concentrations of other samples reliably.
For data that follow a straight line, the standard method for fitting is the linear...
High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte properties and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Deep learning-based dose prediction for MR-guided prostate SIB: Supporting rapid feasibility assessment and adaptive editing margin selection.

Medical physics·2026
Same author

Autologous stem cell transplantation (ASCT) for Refractory juvenile-onset systemic sclerosis (JSSc).

Annals of the rheumatic diseases·2026
Same author

Hepatitis B in pregnancy and breastfeeding: current approaches to prophylaxis and treatment.

Expert review of anti-infective therapy·2026
Same author

Topical 5-fluorouracil versus photodynamic therapy: differential impact on epidermal clonal mutations in early UV-induced skin carcinogenesis.

The Journal of investigative dermatology·2026
Same author

How I Treat: Haploinsufficiency of A20.

Journal of human immunity·2026
Same author

Enhancing the Potency of the Antimalarial Agent, WEHI-601, Through Stereoselective Fluorination.

ChemMedChem·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
Same journal

A novel optical respiratory gating system with a hybrid phase-amplitude algorithm for spot-scanning proton therapy.

Medical physics·2026
Same journal

Gamma Knife treatment planning using knowledge-based reinforcement learning.

Medical physics·2026
Same journal

Development and characterization of a novel, small animal external beam irradiator using a clinical high dose rate brachytherapy source.

Medical physics·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
10:57

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy

Published on: November 11, 2025

An MLC calibration method using a detector array.

Thomas A Simon1, Darren Kahler, William E Simon

  • 1Department of Nuclear and Radiological Engineering, University of Florida, 202 Nuclear Science Building, Gainesville, Florida 32611-8300, USA. tsimon@ufl.edu

Medical Physics
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

A new quantitative calibration method for multileaf collimators (MLC) uses the Profiler 2 detector array to measure leaf positions. This efficient quality assurance tool achieves high accuracy, improving radiation therapy delivery.

More Related Videos

Automatic Laser-based Geometry Capture for Finite Element Analysis of Weld Beads
07:58

Automatic Laser-based Geometry Capture for Finite Element Analysis of Weld Beads

Published on: July 25, 2025

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Related Experiment Videos

Last Updated: Jun 18, 2026

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy
10:57

Mapping Absolute DNA Density in Cell Nuclei using Single-molecule Localization Microscopy

Published on: November 11, 2025

Automatic Laser-based Geometry Capture for Finite Element Analysis of Weld Beads
07:58

Automatic Laser-based Geometry Capture for Finite Element Analysis of Weld Beads

Published on: July 25, 2025

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Quality Assurance

Background:

  • Accurate positioning of multileaf collimator (MLC) leaves is critical for precise radiation therapy delivery.
  • Existing calibration methods may be time-consuming or lack quantitative precision.

Purpose of the Study:

  • To develop and validate a quantitative calibration method for MLC leaf positions using a commercially available detector array.
  • To assess the efficiency and accuracy of this new calibration technique on an Elekta Synergy linear accelerator.

Main Methods:

  • A Profiler 2 detector array was used to measure individual MLC leaf end positions relative to the backup jaw.
  • A half-beam configuration and iterative adjustments were employed for calibration.
  • Results were cross-validated using data from an electronic portal imaging device (EPID).

Main Results:

  • The Profiler 2 method showed excellent agreement with EPID measurements, with an average difference of 0.11+/-0.09 mm per leaf.
  • Leaf positional accuracy of +/-0.4 mm was readily achieved.
  • The entire calibration process for both MLC banks averaged 40 minutes.

Conclusions:

  • The Profiler 2 detector array provides an effective and efficient tool for quantitative MLC quality assurance and calibration.
  • This method enhances the reliability of radiation therapy delivery through precise MLC leaf positioning.