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Nuclear Protein Sorting

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Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
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Anaphase Promoting Complex

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Related Experiment Video

Updated: Jun 18, 2026

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

Nuclear APC.

Kristi L Neufeld¹

¹Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. klneuf@ku.edu

Advances in Experimental Medicine and Biology

|November 26, 2009

Summary

This summary is machine-generated.

Mutational inactivation of the Adenomatous polyposis coli (APC) tumor suppressor gene initiates most colorectal cancers. Nuclear APC opposes beta-catenin transcription, and its disruption promotes cancer progression.

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Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 11, 2014

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Last Updated: Jun 18, 2026

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Artificial Antigen Presenting Cell (aAPC) Mediated Activation and Expansion of Natural Killer T Cells

Published on: December 29, 2012

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Killer Artificial Antigen Presenting Cells (KaAPC) for Efficient In Vitro Depletion of Human Antigen-specific T Cells

Published on: August 11, 2014

Area of Science:

Oncology
Molecular Biology
Cell Biology

Background:

Mutational inactivation of the Adenomatous polyposis coli (APC) gene is a key event in colorectal cancer initiation.
APC protein has diverse subcellular localizations, including the nucleus, cytoplasm, and cell junctions.
Understanding APC's nuclear functions is crucial for cancer research.

Purpose of the Study:

To review the localization and functions of the APC protein within the nucleus.
To elucidate the mechanisms by which nuclear APC regulates gene transcription.
To explore the implications of nuclear APC dysfunction in colorectal cancer progression.

Main Methods:

Review of existing literature on APC protein localization and interactions.
Analysis of APC's nuclear import and export signals.
Examination of APC's role in beta-catenin-mediated transcription and DNA repair.

Main Results:

APC shuttles between the nucleus and cytoplasm via nuclear localization and export signals.
Nuclear APC down-regulates beta-catenin transcription through sequestration and interaction with CtBP.
APC interacts with various nuclear factors, including AP-2alpha, Crm1, PTP-BL, polymerase beta, and PCNA.
Increased cytoplasmic APC correlates with colon cancer progression, suggesting loss of nuclear function.

Conclusions:

Nuclear APC plays a critical role in controlling cell proliferation and opposing oncogenic transcription.
Disruption of nuclear APC functions is implicated in colorectal cancer development.
Further definition of nuclear APC functions may lead to novel diagnostic and therapeutic strategies for colorectal cancer.