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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...

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Related Experiment Video

Updated: Jun 18, 2026

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy
05:21

Real-time Imaging of Myeloid Cells Dynamics in ApcMin/+ Intestinal Tumors by Spinning Disk Confocal Microscopy

Published on: October 6, 2014

APC and its modifiers in colon cancer.

Lawrence N Kwong1, William F Dove

  • 1McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, Wisconsin 53706, USA.

Advances in Experimental Medicine and Biology
|November 26, 2009
PubMed
Summary

Adenomatous polyposis coli (APC) gene mutations are key in colon cancer, driving predisposition. However, diverse genetic and epigenetic factors create the disease's varied spectrum.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Adenomatous polyposis coli (APC) gene mutations are implicated in approximately 80% of human colon tumors.
  • APC gene mutations lead to autosomal dominant colon cancer predisposition in humans and animal models.
  • Colon cancer's phenotypic spectrum arises from complex interactions between genetic and epigenetic factors.

Purpose of the Study:

  • To provide an overview of the structure, function, and unresolved questions regarding APC's role in colon cancer.
  • To explore how genetic and epigenetic factors modify APC-mutant phenotypes in colon carcinogenesis.
  • To connect the central role of APC to the broader factors influencing colon cancer development.

Main Methods:

  • Review of existing literature on APC gene function and colon cancer.

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Published on: August 20, 2018

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Last Updated: Jun 18, 2026

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  • Analysis of genetic and epigenetic factors contributing to colon cancer phenotypes.
  • Utilizing data from genetically tractable animal models for colon cancer research.

    • Main Results:

    • APC gene mutations are a primary driver in a majority of colon cancers.
    • Genetic and epigenetic factors significantly influence the phenotypic variability of colon cancer.
    • Animal models are crucial for identifying genetic modifiers of APC-mutant phenotypes.

    Conclusions:

    • APC is a critical gatekeeper gene in colon cancer, but its role is modulated by other factors.
    • Understanding genetic and epigenetic modifiers is essential for comprehending the full spectrum of colon cancer.
    • Further research using animal models will elucidate the complex pathways of colon carcinogenesis.