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DNA Isolation

DNA Isolation

DNA isolation protocols can be fast and straightforward or complex and time-consuming depending on the type and quality of DNA required for further processing. For example, plasmid DNA extraction is a bit more complicated than genomic DNA extraction because of the need for an appropriate lysis method to separate plasmid DNA from gDNA during isolation. However, for specific applications, such as long-range DNA sequencing that require a good yield of high- quality DNA samples, we need to follow...

DNA Isolation

DNA Isolation

DNA from cells is required for many biotechnology and research applications, such as molecular cloning. To remove and purify DNA from cells, researchers use various methods of DNA extraction. While the specifics of different protocols may vary, some general concepts underlie the process of DNA extraction.

DNA Agarose Gel Electrophoresis

DNA Agarose Gel Electrophoresis

Agarose gel electrophoresis is a laboratory technique commonly used to separate DNA fragments by size. However, it can also be used to isolate and purify DNA fragments using a gel extraction protocol.
Gel extraction follows five major steps: running gel electrophoresis to separate fragments, isolating the individual bands, extracting DNA from those bands, and removing the dye and salts from the extracted mixture to obtain pure DNA.
In cloning experiments, both the insert and vector DNA...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

The DNA Helix

The DNA Helix

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Related Experiment Video

Updated: Jun 18, 2026

Optimization and Comparative Analysis of Plant Organellar DNA Enrichment Methods Suitable for Next-generation Sequencing

Optimization and Comparative Analysis of Plant Organellar DNA Enrichment Methods Suitable for Next-generation Sequencing

Published on: July 28, 2017

[DNA: from Miescher to Venter and beyond].

Marta M Gabryelska¹, Maciej Szymański, Jan Barciszewski

¹Institute of Bioorganic Chemistry, Polish Academy of Sciences, Z. Noskowskiego 12/14, 61-704 Poznań, Poland.

Postepy Biochemii

|November 26, 2009

Summary

Discover the history of Deoxyribonucleic acid (DNA), from its 1869 isolation to the human genome project. Learn about key DNA discoveries and sequencing techniques.

Area of Science:

Molecular Biology
Genetics
Biotechnology

Background:

Trace the discovery of Deoxyribonucleic acid (DNA), starting with Friedrich Miescher's isolation of 'nuclein' in 1869.
Highlight the pivotal 1953 molecular structure model proposed by Watson and Crick, a cornerstone of modern biology.

Discussion:

Explore the evolution of DNA research, encompassing its structure, functions, and applications.
Detail the progression from initial isolation to the comprehensive understanding of the Homo sapiens genome.

Key Insights:

The article chronicles significant DNA discoveries over 140 years, culminating in the human genome sequence.
Emphasizes the foundational role of early DNA research in advancing molecular and chemical biology.

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Last Updated: Jun 18, 2026

Optimization and Comparative Analysis of Plant Organellar DNA Enrichment Methods Suitable for Next-generation Sequencing

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Extraction of High Molecular Weight DNA from Microbial Mats

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Outlook:

Discuss the impact of deep DNA sequencing techniques and their applications.
Underscore the ongoing contributions of DNA research to biotechnology and our understanding of life.