Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Abortion care over 20 weeks gestation: a psychosocial exploration of patient experiences at the Royal Women's Hospital, Victoria, Australia.

Reproductive health·2025

Same author

Clinicians' attitudes towards the undergraduate medical student syllabus in psychiatry.

Irish journal of psychological medicine·2025

Same author

Clinical features of patients who are admitted under different criteria of the Irish Mental Health Act 2001: a retrospective cohort study.

Irish journal of psychological medicine·2025

Same author

The impact of fluphenazine withdrawal: a mirror-image study.

Irish journal of psychological medicine·2024

Same author

Temporal Trends in Severe Brain Injury and Associated Outcomes in Very Preterm Infants.

Neonatology·2024

Same author

A comparison of rate and methods of probable suicide for 2 years pre and post the onset of the COVID-19 pandemic.

Irish journal of psychological medicine·2024

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

D-cycloserine and early ethanol exposure in developing rats.

W L Isaac¹, W F McDaniel, J D Corley

¹Department of Psychology, Georgia College & State University, Milledgeville, GA 31061, USA. walter.isaac@gcsu.edu

Psychological Reports

|November 26, 2009

Summary

D-cycloserine (DCS) may protect offspring from some negative effects of prenatal ethanol exposure. This study investigated DCS and ethanol

More Related Videos

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

Related Experiment Videos

Last Updated: Jun 18, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development

Published on: July 13, 2014

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

Area of Science:

Neuroscience
Developmental Biology
Pharmacology

Background:

Prenatal exposure to ethanol can lead to developmental neurotoxicity.
D-cycloserine (DCS) is an NMDA receptor agonist with potential neuroprotective properties.

Purpose of the Study:

To investigate the effects of prenatal D-cycloserine (DCS) and ethanol exposure on offspring behavior.
To determine if DCS can mitigate the adverse developmental effects of ethanol.

Main Methods:

Pregnant rats received daily treatments of sucrose, DCS, ethanol, or DCS+ethanol via drinking water from gestational day 10/11 to postnatal day 10.
Offspring were assessed for activity in an open field and motor coordination on a rotating rod test during juvenility.

Main Results:

Offspring exposed to ethanol and DCS+ethanol exhibited increased activity in the open field.
Offspring exposed to DCS and DCS+ethanol showed improved motor coordination with fewer falls on the rotating rod test compared to controls.

Conclusions:

D-cycloserine (DCS) may offer protection against some behavioral deficits induced by prenatal ethanol exposure.
These findings suggest a potential therapeutic role for DCS in mitigating developmental neurotoxicity from ethanol.