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Pancreas transplantation. A new program.

J P Boudreaux1, W H Nealon, R C Carson

  • 1Department of Surgery, University of Texas Medical Branch, Galveston.

The American Surgeon
|February 1, 1991
PubMed
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Pancreas transplantation can successfully make insulin-dependent diabetics insulin-independent. Combined pancreas and kidney transplants offer a treatment choice for Type 1 diabetics with kidney issues.

Area of Science:

  • Transplantation Surgery
  • Endocrinology
  • Nephrology

Background:

  • Type 1 diabetes mellitus (T1DM) is a chronic condition requiring lifelong insulin therapy.
  • Pancreatic graft failure and complications can lead to significant morbidity.
  • Combined pancreas-kidney transplantation is an option for T1DM patients with end-stage renal disease.

Purpose of the Study:

  • To evaluate the outcomes of pancreas transplantation in insulin-dependent diabetics.
  • To assess patient and graft survival rates after pancreatico-duodenal transplants.
  • To determine the efficacy of combined pancreas-renal transplantation.

Main Methods:

  • Retrospective analysis of 16 pancreatico-duodenal transplants in 15 T1DM patients (aged 25-46).
  • 14 patients received combined cadaveric pancreas/renal transplants with bladder drainage.

Related Experiment Videos

  • Monitoring of complications, rejection episodes, and graft survival.

    • Main Results:

    • 87% patient and kidney graft survival; 81% pancreas graft survival (1-20 months).
    • All patients achieved insulin independence and normoglycemia (mean HbA1c 4.0% post-transplant).
    • Mean serum creatinine improved to 1.4 mg/dl.

    Conclusions:

    • Pancreas transplantation can be successful in carefully selected T1DM patients.
    • Combined pancreatic/renal transplantation is a viable treatment for T1DM with impaired renal function.
    • Minimizing preservation injury during donor procurement is crucial for pancreas graft success.