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The biochemical basis for stereochemical control in polyketide biosynthesis

Chiara R Valenzano1, Rachel J Lawson, Alice Y Chen

  • 1Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912-9108, USA.

Journal of the American Chemical Society
|November 26, 2009
PubMed
Summary

Polyketide synthases control stereochemistry via ketoreductase domains. Methyl group epimerization occurs after chain elongation, catalyzed by the ketoreductase domain itself.

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