Related Experiment Video
Updated: Jun 18, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
ent-kaurane and ent-pimarane diterpenoids from Siegesbeckia pubescens
Rui Wang1, Wen-Hao Chen, Yan-Ping Shi
1State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
Abstract:
Phytochemical investigation of the above-ground parts of Siegesbeckia pubescens yielded 25 diterpenoids, including five new ent-pimarane diterpenoids (1-3, 11, and 12) and four new ent-kaurane diterpenoids (13-16). The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. Single-crystal X-ray diffraction analysis confirmed the structures of 8, 13, and 14. Seven of these diterpenoids were evaluated for cytotoxic activity against HSC-T6, HeLa, and B16 cell lines. Compounds 11 and 14 exhibited moderate cytotoxicity.
Related Concept Videos
Introduction to Plant Diversity
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Antifungal Agents
Cell Signaling in Plants
Overview of Metabolism
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...