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Updated: Jun 18, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform
Published on: October 20, 2020
Multilayered polyelectrolyte films: from active molecular delivery to vaccine therapy
1Institut National de la Santé et de la Recherche Médicale, 11 rue Humann, Strasbourg, France. jean-claude.voegel@medecine.u-strasbg.fr
Abstract:
A paper in this issue discusses the use of multilayered polyelectrolyte films incorporating a hydrolytically degradable polymer for transcutaneous drug or vaccine delivery. Dried films could be deconstructed rapidly, and a model protein antigen (ovalbumin) and/or immunostimulatory molecules could be released with different kinetics. Both molecules could also be delivered to antigen-presenting cells in the skin (Langerhans cells). The described approach provides a new route for the storage of vaccines. Successful antigen processing and presentation to lymphocytes remain ongoing challenges before the concept can be used in the next generation of vaccines.
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