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Related Experiment Video

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Frugal Imaging Technique of Capillary Flow Through Three-Dimensional Polymeric Printing Powders

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Practical methods for improving flow properties of active pharmaceutical ingredients.

Kalyana C Pingali¹, Kostas Saranteas, Reza Foroughi

¹Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ 09954, USA.

Drug Development and Industrial Pharmacy

|November 26, 2009

Summary

Formulation additives significantly improve active pharmaceutical ingredient (API) powder flow without altering particle characteristics. Electrical properties like impedance correlate with powder cohesiveness and flowability, suggesting a common mechanism for flow improvement.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Powder flow is critical for pharmaceutical manufacturing processes.
Particle size and shape modifications are common but complex methods to improve powder flow.

Purpose of the Study:

To develop formulation strategies for enhancing active pharmaceutical ingredient (API) powder flow properties.
To investigate additive effects on flow without modifying particle size or shape.

Main Methods:

A formulation approach was employed using three distinct APIs: acetaminophen, levalbuterol tartrate, and didesmethylsibutramine tartrate.
Small quantities of lubricants, glidants, and other additives were individually and combinedly mixed with APIs using a V-blender.
Flow index, dilation, and electrical impedance were measured for 24 different blends.

Main Results:

All tested APIs demonstrated improved flow properties upon additive incorporation.
The combination of SiO2, MgSt, and talc significantly reduced cohesiveness and enhanced powder flowability.
A strong correlation was observed between flow index, dilation, and electrical impedance across all APIs.

Conclusions:

Improved powder flow in APIs is associated with low dilation and low electrical impedance values.
Electrical properties play a significant role in API powder cohesivity.
A unified mechanism underlies the development and mitigation of cohesive phenomena in pharmaceutical powders.