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Interactive Molecular Model Assembly with 3D Printing
Published on: August 13, 2020
A novel fast disintegrating tablet fabricated by three-dimensional printing
Deng-Guang Yu1, Chris Branford-White, Yi-Cheng Yang
1Chemical Engineering and Biotechnology, College of Chemistry, Donghua University, Shanghai, China.
Drug Development and Industrial Pharmacy
|November 26, 2009
Summary
Three-dimensional printing (3DP) offers a novel method for creating fast disintegrating tablets (FDTs). This technology enables precise control over tablet structure, leading to improved drug delivery characteristics.
Area of Science:
- Pharmaceutical Technology
- Additive Manufacturing
- Materials Science
Background:
- Computer-aided models and three-dimensional printing (3DP) allow precise control over material composition, microstructure, and surface texture.
- 3DP technology is a valuable tool for developing novel solid dosage forms with unique properties.
Purpose of the Study:
- To design and fabricate a novel fast disintegrating tablet (FDT) utilizing the 3DP process.
- To investigate the structural integrity and drug release characteristics of 3D printed FDTs.
Main Methods:
- A novel FDT was designed and fabricated using a layer-by-layer 3DP process.
- Binder solutions were selectively deposited to form inner powder regions, binding particles together.
Main Results:
- Environmental scanning electron microscopy confirmed bound printed regions with reduced particle distinction.
- Tablets exhibited a hardness of 54.5 N/cm², 0.92% mass loss in friability tests, and rapid disintegration (21.8 seconds).
- In vitro dissolution testing showed 97.7% acetaminophen release within 2 minutes.
Conclusions:
- The 3DP process provides innovative methods for the preparation of fast disintegrating tablets.
- 3DP enables the creation of FDTs with desirable mechanical and rapid drug release properties.
