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Updated: Jun 18, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

The relation between serotonin levels and insufficient blood pressure decrease during night-time in hypertensive

Ramazan Topsakal¹, Nihat Kalay, Ertugrul Emre Gunturk

¹Department of Cardiology, Erciyes University Medicine Faculty, Kayseri, Turkey. nihatkalay@hotmail.com

|November 26, 2009

Summary

Hypertensive patients who do not experience a nocturnal blood pressure drop (non-dippers) have significantly lower thrombocyte serotonin levels. These lower serotonin levels may be linked to insufficient nocturnal blood pressure decrease in hypertension.

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Last Updated: Jun 18, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Area of Science:

Cardiovascular Research
Biochemistry
Hypertension Studies

Background:

Hypertension is a global health concern.
Reduced serotonin levels in thrombocytes are observed in hypertensive individuals.
Nocturnal blood pressure dipping patterns are significant indicators of cardiovascular risk.

Purpose of the Study:

To investigate the association between thrombocyte serotonin levels and the non-dipper phenomenon in hypertensive patients.
To explore the relationship between serotonin levels and nocturnal blood pressure reduction.
To assess potential correlations with other cardiovascular risk markers.

Main Methods:

Fifty-six hypertensive patients and 27 healthy controls were analyzed.
Hypertensive patients were categorized into dipper and non-dipper groups based on nocturnal blood pressure changes.
Thrombocyte serotonin levels, serum uric acid, C-reactive protein (CRP), and urinary albumin/creatinine ratios were measured.

Main Results:

Non-dipper hypertensive patients exhibited significantly lower thrombocyte serotonin levels compared to dippers and controls.
Serotonin levels showed a negative correlation with blood pressure, microalbuminuria, uric acid, and CRP.
Non-dippers presented higher CRP concentrations and microalbuminuria than dippers and controls.

Conclusions:

Thrombocyte serotonin levels are significantly diminished in hypertensive non-dippers.
Reduced serotonin levels may play a role in the pathophysiology of insufficient nocturnal blood pressure decrease.
Further research is warranted to elucidate the precise mechanisms linking serotonin and non-dipping in hypertension.