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Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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Related Experiment Video

Updated: Jun 18, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Proteomics data mining.

Marc Wilkins

    Expert Review of Proteomics
    |November 26, 2009
    PubMed
    Summary
    This summary is machine-generated.

    Marc Wilkins pioneered proteomics, defining the proteome and coining the term. His current research explores protein modifications in biological networks.

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    Area of Science:

    • Biochemistry
    • Systems Biology
    • Molecular Biology

    Background:

    • Pioneering work in defining the proteome and coining the term 'proteomics'.
    • Co-editing the first book on proteomics and co-founding Proteome Systems.
    • Establishing and directing the NSW Systems Biology Initiative.

    Observation:

    • Research focuses on protein post-translational modifications.
    • Investigating the role of these modifications in biological systems.
    • Analyzing their impact on protein-interaction networks.

    Findings:

    • Defined the concept of the proteome.
    • Coined the term 'proteomics'.
    • Current research investigates protein post-translational modifications in regulatory networks.

    Implications:

    • Advanced the field of proteomics through foundational definitions and commercialization.
    • Current research contributes to understanding complex biological regulation.
    • Potential applications in disease research and therapeutic development.