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Updated: Jun 18, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Inverse relationship between serum high density lipoprotein and negative syndrome in antipsychotic-naive
Ganesan Venkatasubramanian1, Rashmi Arasappa, Naren P Rao
1The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. venkat.nimhans@yahoo.com
Background:
Recent literature suggests a role for apolipoprotein L (apoL) aberrations in the pathogenesis of schizophrenia. ApoL is almost exclusively associated with apolipoprotein A-I in high-density lipoproteins (HDLs). The objective of this study was to examine the correlation between symptom scores and serum HDL in antipsychotic-naive schizophrenia patients.
Methods:
In this cross-sectional study, 60 antipsychotic-naive schizophrenia patients were systematically examined for their symptom scores, with good inter-rater reliability. Concurrently, an overnight fasting serum lipid profile from these patients was assessed.
Results:
Serum HDL had a significant inverse correlation with a total negative syndrome score (rho=-0.43; p=0.001).
Conclusions:
The study observation supports the potential role for HDL abnormalities in the genesis of negative symptoms in schizophrenia.
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