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Constraint-induced movement therapy after injection of Botulinum toxin improves spasticity and motor function in

Colleen G Canning1

  • 1The University of Sydney, Australia.

The Australian Journal of Physiotherapy
|November 26, 2009
PubMed
Abstract

No abstract available in PubMed .

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Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...

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