Related Experiment Video
Updated: Jun 18, 2026
05:37
Experimental Model of Ligature-Induced Peri-Implantitis in Mice
Published on: May 17, 2024
Do periodontopathogens disappear after full-mouth tooth extraction?
Nele Van Assche1, Mark Van Essche, Martine Pauwels
1Department of Periodontology, Catholic University Leuven, Leuven, Belgium. nele.vanassche@uz.kuleuven.ac.be
Journal of Clinical Periodontology
|November 26, 2009
Summary
Full-mouth tooth extraction significantly reduces key periodontopathogens like Porphyromonas gingivalis in subgingival plaque. However, these bacteria persist on the tongue and in saliva, indicating extraction does not fully eradicate them.
Area of Science:
- Oral microbiology
- Periodontology
- Infectious diseases
Background:
- Severe, aggressive periodontitis often necessitates radical treatment.
- Full-mouth extraction is considered a drastic measure for advanced periodontal disease.
Purpose of the Study:
- To investigate the impact of full-mouth extraction on intra-oral microbiological changes.
- To quantify the reduction of specific periodontopathogens post-extraction using quantitative polymerase chain reaction (qPCR).
Main Methods:
- Nine patients with severe periodontitis underwent full-mouth extraction.
- Microbial samples from tongue, saliva, and subgingival plaque were collected before and 6 months after extraction.
- Quantitative polymerase chain reaction (qPCR) was used for microbial analysis.
Main Results:
- Extraction led to a 3-log reduction of Porphyromonas gingivalis and Tannerella forsythia in subgingival plaque.
- Modest reductions were observed for Aggregatibacter actinomycetemcomitans and Prevotella intermedia.
- Detection frequencies of these pathogens in saliva and on the tongue remained unchanged.
Conclusions:
- Full-mouth extraction significantly reduces, but does not eradicate, periodontopathogens.
- Persistence of pathogens in saliva and on the tongue suggests alternative reservoirs.
- Clinical implications of incomplete eradication warrant further investigation.
Related Concept Videos
01:27The Oral Microbiota
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:15Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
01:26Tonsillitis II: Management
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.