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The structure of the brain-specific rat aldolase C gene and its regional expression
1Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan.
Biochemical and Biophysical Research Communications
|January 31, 1991
Abstract:
The rat aldolase C gene was isolated from a rat genomic DNA library. This gene comprises 9 exons and spans 3590 base pairs. A single copy of the gene occurs per haploid rat genome. The initiation of transcription occurs at two different sites. The cellular localization of aldolase C mRNA was determined in the central nervous system along with aldolase A mRNA by in situ hybridization. The result indicates the predominant expression of this gene in Purkinje cells of the cerebellar cortex, where aldolase A mRNA was rather repressed.