Glomerulosclerosis following irradiation and cytotoxic therapy for nephroblastoma

A 6-year-old child had a nephrectomy for nephroblastoma followed by radiotherapy and chemotherapy with actinomycin D and vincristine. He died of metastatic disease 13 months after the operation. Autopsy showed a diffuse glomerulosclerosis in the remaining kidney which is attributed to the postoperative therapy.