Related Experiment Video
Updated: Feb 11, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Behavioural deterioration induced by intrahippocampal NAC61-95 injections and attenuation with ibuprofen
Eugene O'Hare1, Jennifer J Elliott, Peter Hobson
1School of Psychology, Queen's University, University Road, Belfast, BT7 1NN, Northern Ireland, UK. e.ohare@qub.ac.uk
Abstract:
Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding. Four groups of rats were used (n=6 per group), subgroups were treated orally with either ibuprofen (40mg/kg) or vehicle (10% sucrose) twice daily. Intrahippocampal injection of NAC(61-95) increased lever switching errors and numbers of activated astrocytes, and ibuprofen treatment alleviated these effects.
More Related Videos
Related Concept Videos
Transcription Attenuation in Prokaryotes
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
Mortar Joint Deterioration in Masonry
The...
Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview
The ATR process begins by directing a beam...
Induced-fit Model
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
Induced Pluripotent Stem Cells
Gas Chromatography: Sample Injection Systems
Two primary injection methods are used...

