The burden of hospitalised rotavirus infections in Fiji

Adam Jenney1, Lisi Tikoduadua, Eka Buadromo

  • 1Centre for International Child Health, Department of Paediatrics, University of Melbourne, Parkville, Victoria 3051, Australia. jenneya@unimelb.edu.au

Vaccine
|November 26, 2009
PubMed

Insights

Rotavirus causes severe diarrhea in young children globally. In Fiji, rotavirus disease is significant, with strain G3[P8] predominant, highlighting the need for rotavirus vaccines.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Rotavirus is a leading cause of severe dehydrating diarrhea in children under five worldwide.
  • Understanding the burden and circulating strains of rotavirus is crucial for public health interventions in Fiji.

Purpose of the Study:

  • To determine the burden of rotavirus disease in hospitalized children in Suva, Fiji.
  • To identify the predominant rotavirus serotypes responsible for acute gastroenteritis in this population.

Main Methods:

  • A hospital-based surveillance study was conducted in Suva, Fiji, during 2006-2007.
  • Stool specimens from 592 children under five admitted with acute diarrhea were analyzed for rotavirus.
  • Rotavirus strains were characterized by serotyping.

Main Results:

  • Rotavirus was detected in 39% of the 454 tested stool specimens.
  • The most common rotavirus serotype identified was G3[P8].
  • A significant burden of rotavirus disease was observed in young children in Fiji.

Conclusions:

  • Rotavirus poses a substantial public health challenge in Fiji.
  • The findings support the potential impact of rotavirus vaccines in reducing severe diarrheal disease and hospitalizations in Fiji.

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Reservoir of Infection01:30

Reservoir of Infection

Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...