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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
The burden of hospitalised rotavirus infections in Fiji
Adam Jenney1, Lisi Tikoduadua, Eka Buadromo
1Centre for International Child Health, Department of Paediatrics, University of Melbourne, Parkville, Victoria 3051, Australia. jenneya@unimelb.edu.au
Insights
Rotavirus causes severe diarrhea in young children globally. In Fiji, rotavirus disease is significant, with strain G3[P8] predominant, highlighting the need for rotavirus vaccines.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Rotavirus is a leading cause of severe dehydrating diarrhea in children under five worldwide.
- Understanding the burden and circulating strains of rotavirus is crucial for public health interventions in Fiji.
Purpose of the Study:
- To determine the burden of rotavirus disease in hospitalized children in Suva, Fiji.
- To identify the predominant rotavirus serotypes responsible for acute gastroenteritis in this population.
Main Methods:
- A hospital-based surveillance study was conducted in Suva, Fiji, during 2006-2007.
- Stool specimens from 592 children under five admitted with acute diarrhea were analyzed for rotavirus.
- Rotavirus strains were characterized by serotyping.
Main Results:
- Rotavirus was detected in 39% of the 454 tested stool specimens.
- The most common rotavirus serotype identified was G3[P8].
- A significant burden of rotavirus disease was observed in young children in Fiji.
Conclusions:
- Rotavirus poses a substantial public health challenge in Fiji.
- The findings support the potential impact of rotavirus vaccines in reducing severe diarrheal disease and hospitalizations in Fiji.
Abstract:
Rotavirus is the most common cause of acute severe dehydrating diarrhoea in young children worldwide. We describe the burden of rotavirus disease and the rotavirus types causing it in the largest city in Fiji. During 2006 and 2007, 592 children under 5 years of age were admitted to hospital in Suva, Fiji with acute diarrhoea. Of the 454 children for whom a stool specimen was tested, 39% were positive for rotavirus and the predominant strain found was the serotype G3[P8]. There is a significant burden of disease due to rotavirus in Fiji and the introduction of rotavirus vaccines into the national immunization schedule may drastically reduce inpatient diarrhoeal disease.
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