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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Human rotavirus genotypes in hospitalized children, South Korea, April 2005 to March 2007

S Y Lee1, S K Hong, S G Lee

  • 1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, South Korea.

Vaccine
|November 26, 2009
PubMed

Insights

Rotavirus surveillance in South Korea identified G1P[8] as the most common strain among children with gastroenteritis. This study provides crucial data on rotavirus genotype distribution and seasonal patterns.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Rotavirus is a leading cause of severe gastroenteritis in children globally.
  • The introduction of rotavirus vaccines necessitates ongoing strain surveillance.
  • Understanding local rotavirus epidemiology is vital for public health interventions.

Purpose of the Study:

  • To conduct large-scale rotavirus strain surveillance in South Korea.
  • To identify the prevalent G and P genotypes of rotavirus.
  • To analyze seasonal patterns of rotavirus infection.

Main Methods:

  • Collection of stool samples from children with gastroenteritis across eight hospitals in South Korea (April 2005 - March 2007).
  • Detection of rotavirus using antigen detection assays.
  • Genotyping of G and P strains for rotavirus-positive specimens.

Main Results:

  • 1337 out of 6057 (22%) samples were positive for rotavirus.
  • G1P[8] was the most prevalent genotype (36%), followed by G3P[8] (16%), G4P[6] (8.9%), and G1P[6] (8.2%).
  • Rotavirus infection showed seasonal peaks from November 2005 to April 2006 and January to March 2007.

Conclusions:

  • G1P[8] is the dominant rotavirus strain in South Korea.
  • This surveillance provides valuable data on rotavirus genotype distribution and temporal changes.
  • Findings support the need for continued rotavirus surveillance to inform vaccination strategies.

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