Related Experiment Video
Updated: Jun 18, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
Delayed salicylate toxicity with undetectable initial levels after large-dose aspirin ingestion
Joseph Herres1, Danielle Ryan, Matthew Salzman
1Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, USA.
Abstract:
Aspirin (acetylsalicylic acid), the most commonly used medicinal salicylate, is an antiinflammatory, antipyretic, antirheumatic, and analgesic agent. In 2005, according to the Toxic Exposures Survey from the American Association of Poison Control Centers' National Poisoning and Exposure Database, there were more than 20,000 reported aspirin and nonaspirin salicylate exposures, 64% of which required treatment in a health care facility. Of these exposures, 50% were reported as intentional overdoses and 60 patients died.
Related Concept Videos
Prevention of Further Absorption of Poison
Drug toxicity: Drug–Drug Interaction
Drug Toxicity: Dose-Dependent Reactions
Pharmaceutical Poisoning: Treatment Strategies
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug Toxicity: Overview
