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Updated: Jun 18, 2026
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
New antibiotics: optimal use in current clinical practice
Drosos E Karageorgopoulos1, Matthew E Falagas
1Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece.
International Journal of Antimicrobial Agents
|November 26, 2009
Summary
Newer antibiotics offer vital options for treating resistant bacterial infections. This review details effective treatments for methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and multidrug-resistant Streptococcus pneumoniae.
Area of Science:
- Infectious Diseases
- Pharmacology
- Microbiology
Background:
- Antimicrobial resistance (AMR) poses a significant global health threat, necessitating the development of novel antibacterial agents.
- Limited therapeutic options exist for infections caused by highly resistant pathogens, complicating treatment and increasing mortality.
- Optimizing antibacterial therapy is crucial for clinical success and preventing further resistance.
Purpose of the Study:
- To review the clinical effectiveness of antibiotics introduced in the last decade.
- To identify optimal treatment strategies for infections caused by multidrug-resistant organisms (MDROs).
- To guide the selection of appropriate therapies for specific resistant bacterial infections.
Main Methods:
- Systematic review of clinical data on recently introduced antibiotics.
- Analysis of treatment efficacy for specific pathogens and clinical indications.
- Evaluation of antibiotics against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), and multidrug-resistant Streptococcus pneumoniae (MDRSP).
Main Results:
- Quinupristin-dalfopristin, linezolid, daptomycin, and tigecycline provide options for MRSA and VRE infections.
- Moxifloxacin, gemifloxacin, telithromycin, and cefditoren are valuable for MDRSP infections.
- Tigecycline, ertapenem, and doripenem show promise against ESBL-producing Enterobacteriaceae and resistant Acinetobacter baumannii and Pseudomonas aeruginosa.
Conclusions:
- Recent antibiotic advancements have expanded therapeutic choices for challenging resistant infections.
- Careful selection of these newer agents is essential for effective treatment and AMR containment.
- These drugs offer critical alternatives for infections caused by difficult-to-treat Gram-positive and Gram-negative bacteria.
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