Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

Oral Drug Delivery Systems: Delayed-Release Systems

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are typically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Corrigendum to "Pharmaceutical optimization of chitosan tablets is associated with reduced circulating bile acids and fibrosis-related molecular signatures in non-alcoholic steatohepatitis rats" [Carbohydrate Polymers 383 (2026) 125333].

Carbohydrate polymers·2026

Same author

Pharmaceutical optimization of chitosan tablets is associated with reduced circulating bile acids and fibrosis-related molecular signatures in non-alcoholic steatohepatitis rats.

Carbohydrate polymers·2026

Same author

Preparation and evaluation of hydrophobin-pirarubicin glucosamine-containing nanoparticles as an anticancer formulation.

International journal of biological macromolecules·2026

Same author

Guanidinylated Chitosan as a Multifunctional Enhancer for Improved Flurbiprofen Delivery.

Biological & pharmaceutical bulletin·2025

Same author

The preparation and evaluation of granulated chitosan-catechin tablets with excellent disintegration properties.

Carbohydrate research·2024

Same author

[Changes in Attitudes to Medical Care among Pharmacy Pharmacists before and after the COVID-19 Pandemic: A Questionnaire Survey].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·2023

Search research articles

Related Experiment Video

Updated: Jun 18, 2026

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Published on: August 15, 2025

Polysaccharides as potential antioxidative compounds for extended-release matrix tablets.

Hisao Tomida¹, Taira Yasufuku, Takeshi Fujii

¹Faculty of Pharmacy and Pharmaceutical Sciences, Department of Physical Pharmaceutics, Fukuyama University, 1 Sanzo, Gakuen-cho, Fukuyama 729-0292, Japan. tomida@fupharm.fukuyama-u.ac.jp

Carbohydrate Research

|November 26, 2009

Summary

Low molecular weight chitosan and pectic acid exhibit potent antioxidant properties, making them suitable for extended-release drug delivery systems. An interpolymer complex of these compounds demonstrated effective antioxidant activity and controlled drug release.

More Related Videos

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

Related Experiment Videos

Last Updated: Jun 18, 2026

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Published on: August 15, 2025

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

Generation of Alginate Microspheres for Biomedical Applications

Generation of Alginate Microspheres for Biomedical Applications

Published on: August 12, 2012

Area of Science:

Materials Science
Pharmaceutical Sciences
Biochemistry

Background:

Polysaccharides are explored for their antioxidant potential in pharmaceutical applications.
Developing effective antioxidant compounds is crucial for combating oxidative stress.
Extended-release drug delivery systems require stable and functional matrix components.

Purpose of the Study:

To identify polysaccharides with antioxidant properties for extended-release matrix tablets.
To evaluate the antioxidant capacity of alginate, chitosan, and pectic acid derivatives.
To assess the potential of a pectic acid and low molecular weight chitosan interpolymer complex for drug delivery.

Main Methods:

Assessed antioxidant properties using DPPH and ABTS radical scavenging assays.
Measured reducing power by assessing the ability to reduce Cu(2+).
Formulated and tested an interpolymer complex (IPC) tablet with theophylline as a model drug for extended release.

Main Results:

Low molecular weight chitosan (L-chitosan) and pectic acid (PA) demonstrated significant radical scavenging abilities and reducing power.
High molecular weight chitosan and alginate derivatives showed limited antioxidant effectiveness.
The TPH/PA/L-chitosan IPC tablet exhibited slower theophylline release compared to PA-only or L-chitosan-only tablets.
Optimal complexation ratio for PA/L-chitosan IPC was determined as 1/3 based on turbidity measurements.

Conclusions:

L-chitosan and PA are effective antioxidants with potential for pharmaceutical use.
An interpolymer complex of L-chitosan and PA can serve as a matrix for extended-release drug delivery.
The developed L-chitosan/PA complex exhibits high antioxidant activity and controlled drug release properties.