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Published on: December 10, 2020
Predictive factors for cerebrovascular accidents after thoracic endovascular aortic repair
Giovanni Mariscalco1, Gabriele Piffaretti, Matteo Tozzi
1Department of Surgical Sciences-Cardiac Surgery, Varese University Hospital, University of Insubria, Varese, Italy.
Insights
Cerebrovascular accidents after thoracic endovascular aortic repair are predicted by incomplete Willis circle anatomy and coronary artery disease. Preoperative evaluation of cerebral circulation is crucial for patient selection.
Area of Science:
- Vascular Surgery
- Neurology
- Cardiology
Background:
- Cerebrovascular accidents (CVAs) are significant complications following thoracic endovascular aortic repair (TEVAR).
- Identifying predictors of CVAs after TEVAR is crucial for improving patient outcomes.
Purpose of the Study:
- To determine predictors of cerebrovascular accidents after thoracic endovascular aortic repair.
Main Methods:
- Prospective enrollment of 76 patients undergoing TEVAR between 2001 and 2008.
- Hourly postoperative neurologic assessments were performed to detect deficits.
- CVAs were diagnosed via clinical examination, imaging (CT/MRI), or autopsy.
Main Results:
- CVAs occurred in 10.5% of patients (4 transient ischemic attacks, 4 major strokes).
- Incomplete Willis circle anatomy (OR 17.19) and coronary artery disease (OR 6.86) were independent predictors of postoperative CVAs.
- Hospital mortality was 9.2%, with no significant difference between patients with and without CVAs.
Conclusions:
- Coronary artery disease and Willis circle anomalies are independent predictors of CVAs post-TEVAR.
- Mandatory evaluation of arch vessels and cerebral vascularization is recommended for TEVAR candidates.
Background:
Cerebrovascular accidents are devastating and worrisome complications after thoracic endovascular aortic repair. The aim of this study was to determine cerebrovascular accident predictors after thoracic endovascular aortic repair.
Methods:
Between January 2001 and June 2008, 76 patients treated with thoracic endovascular aortic repair were prospectively enrolled. The study cohort included 61 men; mean age was 65.4 +/- 16.8 years. All patients underwent a specific neurologic assessment on an hourly basis postoperatively to detect neurologic deficits. Cerebrovascular accidents were diagnosed on the basis of physical examination, tomography scan or magnetic resonance imaging, or autopsy.
Results:
Cerebrovascular accidents occurred in 8 (10.5%) patients, including 4 transient ischemic attack and 4 major strokes. Four cases were observed within the first 24-hours. Multivariable analysis revealed that anatomic incompleteness of the Willis circle (odds ratio [OR] 17.19, 95% confidence interval [CI] 2.10 to 140.66), as well as the presence of coronary artery disease (OR 6.86, 95 CI% 1.18 to 40.05), were independently associated with postoperative cerebrovascular accident development. Overall hospital mortality was 9.2%, with no significant difference for patients hit by cerebrovascular accidents (25.0% vs 7.3%, p = 0.102).
Conclusions:
Preexisting coronary artery disease, reflecting a severe diseased aorta and anomalies of Willis circle are independent cerebrovascular accident predictors after thoracic endovascular aortic repair procedures. A careful evaluation of the arch vessels and cerebral vascularization should be mandatory for patients suitable for thoracic endovascular aortic repair.
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