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Electrochemical determination of morphine at ordered mesoporous carbon modified glassy carbon electrode
Fei Li1, Jixia Song, Changsheng Shan
1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied, Chemistry, Graduate University of the Chinese Academy of Sciences, Chinese, Academy of Sciences, Changchun, PR China.
Abstract:
A sensitive electrochemical detection scheme for morphine has been proposed by utilizing the ordered mesoporous carbon modified glassy carbon electrode (OMC/GCE). The electrochemical behaviour of morphine at the OMC/GCE was investigated by cyclic voltammetry. The modified electrode displayed a decrease in the overpotential (ca. 82mV) and an obvious increase in the peak current (80 times) compared to the bare glassy carbon electrode (GCE). The results indicated that OMC/GCE remarkably enhanced electrocatalytic activity towards the oxidation of morphine. Linear response was found over the range from 0.1 microM to 20 microM with a high sensitivity of 1.74 microA/microM and low detection limit of 10 nM (S/N=3). And the relative standard deviation was 0.86% (n=5). Moreover, combining with a medium-exchange procedure, the OMC/GCE has also been successfully applied to the selective determination of morphine in urine samples with a low detection limit of 50 nM and satisfied recovery of 96.4%. The good results indicate that the OMC/GCE holds great promise in practical application.
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