Related Experiment Video
Updated: Jun 18, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Ipsilateral and contralateral acoustic brainstem response abnormalities in patients with vestibular schwannoma
Chien Shih1, Fen-Yu Tseng, Te-Hei Yeh
1Department of Otolaryngology, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
Objective:
To analyze auditory brainstem response (ABR) data in patients with vestibular schwannomas (VS) in an effort to identify correlations between abnormal ABR parameters and tumor size.
Study Design:
Cross-sectional study with chart review.
Setting:
Tertiary referral hospital.
Subjects And Methods:
Retrospective chart review and analysis of bilateral ABR records in patients with VS. Interaural latency differences of interpeak I-V (ILD-I-V) and ILD-V longer than 0.2 ms were used as abnormal criteria.
Results:
Thirty patients with a mean age of 50 +/- 14 years were included in this study. The most frequent changes in ABR parameters included those of ILD-I-V (100%), wave V latency (96.7%), ILD-V (93.3%), and interpeak I-V latency (90%). Average VS tumor size was 2.48 +/- 1.31 cm. For patients with VS greater than or equal to 2 cm, the prevalences of abnormal ipsilateral interpeak III-V latency, contralateral wave V latency, and interpeak III-V latency showed statically significant differences (P = 0.0035, P = 0.0267, and P = 0.0273, respectively) compared to those in patients with VS less than 2 cm. Tumor size was positively correlated with pure-tone average (P = 0.0106) and with the total number of bilateral abnormal ABR parameters (P = 0.004).
Conclusions:
We identified a correlation between ABR parameters and VS tumor size. An ipsilateral ILD-I-V greater than 0.2 ms was sensitive for detecting VS. Abnormal contralateral wave V and interpeak III-V latency indicated a tumor size potentially larger than 2 cm. Further studies are needed to confirm these findings.
Related Concept Videos
Equilibrium and Balance
The Vestibular System
Major Somatic Sensory Pathways
The Cochlea
Anatomy of the Ear
