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"Jumping" translocations involving band 3q13.3 in a case of acute monocytic leukemia
M D Reis1, I D Dubé, P H Pinkerton
1Department of Laboratory Hematology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.
Cancer Genetics and Cytogenetics
|February 1, 1991
Abstract:
We report a case of acute monocytic leukemia (FAB-5a) with a very aggressive clinical course and multiple chromosomal abnormalities. There were several sublines, each with trisomy 8 and a translocation involving 3q13.3 as a common breakpoint region. This region is an uncommon site of chromosomal breakage in malignancies and has not hitherto been reported as a breakpoint site in "jumping" translocations.