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New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia
D F Callen1, Y J Hull, I R Toogood
1Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.
Cancer Genetics and Cytogenetics
|February 1, 1991
Abstract:
The karyotype 47,XX, + 8,t(12;22)(p13;q12) was found at diagnosis in two patients with acute nonlymphocytic leukemia (ANLL). The bone marrow morphology of both patients corresponded to the M4 subtype of the French-American-British (FAB) classification. The translocation t(12;22) has not previously been reported as the sole structural aberration in ANLL.