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Trisomy 5 in Ph+ chronic myeloid leukemia in association with megakaryocytosis
S M Ansell1, B L Rapoport, M A Coccia-Portugal
1Department of Medical Oncology, University of Pretoria, Republic of South Africa.
Cancer Genetics and Cytogenetics
|February 1, 1991
Abstract:
A patient with a megakaryocytosis associated with a Philadelphia chromosome-positive chronic myeloid leukemia (CML) was found to have a trisomy of chromosome five. To our knowledge, this is the first case of trisomy 5 associated with a Ph + CML, particularly one with a megakaryocytosis. The trisomy 5 may be associated with the resistance to cytostatic drugs found in this patient.