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The association between metabolic syndrome and coronary artery disease in Jordan

Yousef S Khader1, Basheer Khasawneh, Ammar K Daoud

  • 1Department of Community Medicine, Public Health and Family Medicine, Faculty of Medicine, Jordan University of Science & Technology, Irbid 22110, Jordan. yousef.k@excite.com

Chronic Illness
|November 26, 2009
PubMed

Insights

Metabolic syndrome (MeS) significantly increases the likelihood of coronary artery disease (CAD) in Jordan. Identifying MeS is crucial for targeted cardiovascular risk reduction strategies in the Jordanian population.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Public Health

Background:

  • High prevalence of metabolic syndrome (MeS) and its components noted in Jordan.
  • Limited data existed on the association between MeS and coronary artery disease (CAD) in the Jordanian population.
  • This study addresses the gap in understanding the MeS-CAD relationship in Jordan.

Purpose of the Study:

  • To investigate the association between metabolic syndrome (MeS) and coronary artery disease (CAD) among Jordanians.
  • To quantify the risk of CAD in individuals with MeS in Jordan.

Main Methods:

  • A case-control study design was employed.
  • Included 269 CAD patients (cases) and 1026 subjects without CAD (controls).
  • MeS diagnosis followed National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria.

Main Results:

  • Metabolic syndrome (MeS) was present in 65.1% of CAD patients versus 44.0% of controls (p<0.0005).
  • Individuals with MeS had nearly double the odds of having CAD (OR = 1.94, 95% CI: 1.29-2.93, p=0.002) after multivariate adjustment.
  • A dose-response relationship was observed, with more metabolic abnormalities correlating with higher CAD risk.

Conclusions:

  • Metabolic syndrome (MeS) is significantly associated with coronary artery disease (CAD) in the Jordanian population.
  • High prevalence of MeS underscores its clinical importance in identifying individuals at elevated cardiovascular risk.
  • Early identification of MeS can guide interventions to reduce cardiovascular risk in Jordan.
Abstract

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