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Gout: an independent risk factor for all-cause and cardiovascular mortality

Chang-Fu Kuo1, Lai-Chu See, Shue-Fen Luo

  • 1Graduate Institute of Clinical Medical Sciences, Chang Gung University, Kwei-Shan Tao-Yuan, Taiwan.

Rheumatology (Oxford, England)
|November 26, 2009
PubMed

Insights

Gout is linked to a higher risk of death from all causes and cardiovascular diseases, while hyperuricaemia alone does not show this association. This study highlights gout as a significant survival risk factor.

Area of Science:

  • Cardiovascular Health
  • Rheumatology
  • Epidemiology

Background:

  • The relationship between gout, hyperuricaemia, and cardiovascular diseases is established.
  • Further investigation is needed to clarify the independent impact of gout and hyperuricaemia on survival.

Purpose of the Study:

  • To investigate the survival impact of gout and hyperuricaemia.
  • To determine the association between these conditions and all-cause and cardiovascular mortality.

Main Methods:

  • Utilized data from a health screening program in Taiwan (2000-2006).
  • Ascertained death status and causes using the Taiwan National Death Registry (2000-2007).
  • Employed Cox proportional hazard models to analyze associations.

Main Results:

  • Among 61,527 subjects, gout was associated with significantly higher all-cause mortality (HR 1.46) and cardiovascular mortality (HR 1.97) compared to normouricaemia.
  • Hyperuricaemia alone did not show a statistically significant increase in all-cause (HR 1.07) or cardiovascular mortality (HR 1.08).
  • The elevated risk for gout persisted even in individuals with estimated glomerular filtration >60 ml/min/1.73 m(2).

Conclusions:

  • Gout, independent of hyperuricaemia, is associated with an increased risk of mortality.
  • Hyperuricaemia, in the absence of gout, does not appear to significantly impact survival.
  • These findings underscore the importance of managing gout for improving patient outcomes.
Abstract

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