Modelling the impact of pandemic influenza A(H1N1) on UK paediatric intensive care demand

A Ercole1, D K Menon, D R O'Donnell

  • 1Cambridge University Department of Anaesthesia, Box 93, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, UK. ae105@cam.ac.uk

Insights

Pandemic influenza A(H1N1) may significantly increase demand for UK paediatric intensive care units (PICUs). Regional variations in critical care provision necessitate enhanced paediatric retrieval services to manage increased winter activity.

Area of Science:

  • Pediatric Intensive Care
  • Epidemiology
  • Public Health

Background:

  • Seasonal respiratory viruses cause significant unplanned admissions to UK paediatric intensive care units (PICUs).
  • Pandemic influenza A(H1N1) disproportionately affects children, potentially straining PICU resources.

Purpose of the Study:

  • To project paediatric intensive care unit (PICU) demand during a pandemic using current data.
  • To analyze the impact of regional variations in critical care bed availability on pandemic preparedness.

Main Methods:

  • Utilized the FluSurge 2.0 model for demand estimation.
  • Employed age-stratified UK population data and conservative epidemiological parameters.

Main Results:

  • A substantial portion of existing paediatric intensive care unit (PICU) capacity may be required during the pandemic peak.
  • Significant regional disparities in critical care provision exist across the UK, leading to varied pandemic impacts.

Conclusions:

  • Contingency planning is essential to address the anticipated rise in paediatric intensive care needs due to pandemic influenza.
  • Paediatric retrieval services are crucial, especially given the uneven distribution of critical care resources regionally.
Abstract

Related Concept Videos

Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...