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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

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Related Experiment Video

Updated: Jun 18, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

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H-InvDB in 2009: extended database and data mining resources for human genes and transcripts.

Chisato Yamasaki1, Katsuhiko Murakami, Jun-ichi Takeda

  • 1BIRC, NIG Waterfront Bio-IT Research Building, 4-7 Aomi, Tokyo 135-0064, Japan.

Nucleic Acids Research
|November 26, 2009
PubMed
Summary

The H-Invitational Database (H-InvDB) now offers expanded resources for human gene and transcript annotation. This update includes new data mining tools like Navigation search and the H-InvDB Enrichment Analysis Tool (HEAT) for enhanced data accessibility.

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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • The H-Invitational Database (H-InvDB) is a crucial resource for human gene and transcript annotation.
  • Previous versions provided foundational data for researchers in human genetics.

Purpose of the Study:

  • To announce the release of an updated H-InvDB with extended database and data mining functionalities.
  • To enhance accessibility and analytical capabilities for human genomic data.

Main Methods:

  • The latest release (6.2) annotates 219,765 human transcripts across 43,159 gene clusters using full-length cDNA and mRNA data.
  • Integration of new features including microarray probe mapping, novel gene models, ncRNA relations, and Glycogene database information.
  • Development of advanced data mining tools: Navigation search and H-InvDB Enrichment Analysis Tool (HEAT).

Main Results:

  • H-InvDB release 6.2 provides comprehensive annotation for a large set of human transcripts and gene clusters.
  • New features facilitate deeper analysis, including identification of specific gene set characteristics via HEAT.
  • Web service APIs (SOAP and REST) are now available for programmatic data access.

Conclusions:

  • The updated H-InvDB significantly enhances the utility of human genomic data for research.
  • Expanded data mining and accessibility features empower researchers with advanced analytical tools.