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Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid
Asma Lat1, George R Thompson, Michael G Rinaldi
1South Texas Veterans Affairs Health Care System, 4502 Medical Drive, San Antonio, TX 78229, USA.
Antimicrobial Agents and Chemotherapy
|November 26, 2009
Summary
Micafungin showed low concentrations in brain tissue and pancreatic fluid in patients with invasive candidiasis. Further research is needed to confirm its effectiveness for these specific fungal infections.
Area of Science:
- Pharmacology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Invasive candidiasis requires effective antifungal treatment.
- Micafungin is an echinocandin antifungal agent.
- Understanding drug penetration into specific body sites is crucial for treatment efficacy.
Purpose of the Study:
- To determine micafungin concentrations in brain tissue and pancreatic pseudocyst fluid.
- To assess micafungin's penetration into the central nervous system (CNS) and pancreatic fluid.
- To evaluate potential alternative uses of micafungin in treating specific candidal infections.
Main Methods:
- Measurement of micafungin concentrations in biological samples.
- Analysis of pharmacokinetic data from two patients with invasive candidiasis.
- Case study reporting drug levels in brain tissue and pancreatic pseudocyst fluid.
Main Results:
- Low concentrations of micafungin were detected in both brain tissue and pancreatic pseudocyst fluid.
- Micafungin demonstrated limited penetration into CNS tissue.
- Micafungin exhibited limited penetration into pancreatic fluid.
Conclusions:
- Micafungin penetration into brain tissue and pancreatic fluid is limited.
- Further pharmacokinetic studies are required for these sites.
- Micafungin might be a potential alternative for refractory CNS or pancreatic candidiasis.
