Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in stress echocardiography: myocardial work for myocardial ischemia detection.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026
Same author

Hypercontractile phenotype at rest in chronic coronary syndromes predicts impaired functional reserve and increased mortality.

ESC heart failure·2026
Same author

Dynamic disorder is crucial for mitochondrial protein import.

Protein science : a publication of the Protein Society·2026
Same author

Prognostic value of multi-marker stress echocardiography.

Future cardiology·2026
Same author

Moderate ischemic mitral regurgitation at rest is associated with multiple functional vulnerabilities during exercise stress echocardiography.

The international journal of cardiovascular imaging·2026
Same author

Inactivation of cofilin-1 in Mcpt5-Cre-nf-Cfl1<sup>fl/fl</sup> mice prevents the formation of connective tissue mast cells without affecting basophils: a new tool to investigate the specific role of CTMCs in disease.

Frontiers in immunology·2026

Related Experiment Video

Updated: May 10, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Persistent diastolic dysfunction late after valve replacement in severe aortic regurgitation.

Bruno Villari1, Samuel Sossalla, Quirino Ciampi

  • 1Division of Cardiology, Fatebenefratelli Hospital of Benevento, Benevento, Italy.

Circulation
|November 26, 2009
PubMed
Summary

Aortic valve replacement normalizes left ventricular (LV) hypertrophy in patients with aortic regurgitation, but persistent fiber hypertrophy and diastolic dysfunction remain, impacting LV function long-term.

More Related Videos

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse
08:12

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

Published on: August 30, 2022

Related Experiment Videos

Last Updated: May 10, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement
14:14

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
04:48

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Published on: November 28, 2018

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse
08:12

Surgically Induced Cardiac Volume Overload by Aortic Regurgitation in Mouse

Published on: August 30, 2022

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Cardiovascular Research

Background:

  • Left ventricular (LV) hypertrophy and diastolic dysfunction are common in chronic aortic regurgitation.
  • Previous studies show regression of LV hypertrophy after aortic valve replacement (AVR) in aortic stenosis.
  • The impact of AVR on LV function and structure in aortic regurgitation requires further evaluation.

Purpose of the Study:

  • To assess the early and late effects of AVR on LV function and structure in patients with chronic aortic regurgitation.

Main Methods:

  • Eleven patients with severe aortic regurgitation underwent LV biplane angiograms, pressure measurements, and endomyocardial biopsies before and after AVR (21 and 89 months).
  • LV systolic function (ejection fraction, midwall fractional shortening) and diastolic function (relaxation time constant, peak filling rates, stiffness constant) were evaluated.
  • LV structure was assessed via muscle fiber diameter, interstitial fibrosis, and fibrous content.

Main Results:

  • LV muscle mass significantly decreased by 55% late after AVR.
  • LV relaxation normalized late after AVR, while ejection fraction remained unchanged.
  • Diastolic stiffness remained elevated post-AVR, and interstitial fibrosis decreased late after surgery.

Conclusions:

  • AVR leads to normalization of macroscopic LV hypertrophy in aortic regurgitation patients.
  • However, persistent fiber hypertrophy and diastolic dysfunction are observed late after AVR.
  • These structural changes correlate with altered passive elastic properties and persistent diastolic dysfunction.