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Related Concept Videos

Renal Corpuscle01:20

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

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Factors Affecting Renal Clearance: Renal Impairment01:17

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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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Related Experiment Video

Updated: Jun 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Urinary properdin excretion is associated with intrarenal complement activation and poor renal function.

Machiel A Siezenga1, Reinier N van der Geest, Marko J K Mallat

  • 1Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands. m.a.siezenga@lumc.nl

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|November 26, 2009
PubMed
Summary

Urinary properdin, a protein, indicates increased complement activation in proteinuric kidney disease. Its presence correlates with higher SC5b-9 levels, suggesting a role in renal damage progression.

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Last Updated: Jun 18, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Area of Science:

  • Nephrology
  • Immunology
  • Complement System Biology

Background:

  • Proteinuria is a marker for progressive renal failure and tubulointerstitial toxicity.
  • Complement activation in proteinuric states contributes to renal tubular cell damage.
  • Properdin is implicated in promoting intrarenal complement activation.

Purpose of the Study:

  • To measure urinary properdin levels in proteinuric patients.
  • To assess the relationship between urinary properdin and urinary SC5b-9 (complement activation marker).

Main Methods:

  • Studied 70 patients with protein excretion ≥ 1 g/day.
  • Measured urinary properdin and SC5b-9 using ELISA.

Main Results:

  • Properdin detected in 53% of patients.
  • Properdin excretion associated with significantly higher urinary SC5b-9 levels (P < 0.001).
  • Properdin excretion linked to worse renal function.

Conclusions:

  • Urinary properdin enhances intrarenal complement activation.
  • Properdin may contribute to renal damage progression in proteinuric states.