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The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration

Jeanne M Bristow1, Meredith H Sellers, Devi Majumdar

  • 1Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA.

Journal of Cell Science
|November 26, 2009
PubMed
Summary

Asef2 regulates cell migration and adhesion dynamics by modulating actin. This study shows Asef2 is crucial for cell movement and rapid adhesion turnover, impacting Rho-family GTPase activity.

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