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Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Negative Regulator Molecules01:23

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

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Generating a "Humanized" Drosophila S2 Cell Line Sensitive to Pharmacological Inhibition of Kinesin-5
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p57KIP2: "Kip"ing the cell under control.

Ioannis S Pateras1, Kalliopi Apostolopoulou, Katerina Niforou

  • 1Molecular Carcinogenesis Group, Laboratory of Histology-Embryology, Medical School, University of Athens, Greece.

Molecular Cancer Research : MCR
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

The p57(KIP2) gene, a cyclin-dependent kinase inhibitor, plays a crucial role in embryogenesis and acts as an anti-oncogene. Its dysregulation is linked to Beckwith-Wiedemann Syndrome and cancer development.

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11:09

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Published on: December 5, 2017

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • p57(KIP2) is a cyclin-dependent kinase inhibitor in the CIP/KIP family, located at 11p15.5.
  • It is less studied than p21(CIP1/WAF1) and p27(KIP1) but has unique roles in embryogenesis and cell cycle regulation.
  • Novel functions, including cytoskeletal organization, are being discovered for p57(KIP2).

Purpose of the Study:

  • To provide a comprehensive analysis of p57(KIP2) in relation to p21(CIP1/WAF1) and p27(KIP1).
  • To review the gene and protein structure, transcriptional and translational regulation of p57(KIP2).
  • To focus on the role of p57(KIP2) in human physiology and pathology, particularly in cancer development.

Main Methods:

  • Literature review and data analysis.
  • Comparative analysis of p57(KIP2) with p21(CIP1/WAF1) and p27(KIP1).
  • Focus on molecular analysis of animal models and human patients.

Main Results:

  • p57(KIP2) is implicated in the pathogenesis of Beckwith-Wiedemann Syndrome.
  • Down-regulation of p57(KIP2) in malignancies indicates its anti-oncogenic function.
  • p57(KIP2) regulates the cell cycle and cytoskeletal organization.

Conclusions:

  • p57(KIP2) is a significant tumor suppressor gene with critical roles in development and cell cycle control.
  • Understanding p57(KIP2) regulation and function is vital for comprehending Beckwith-Wiedemann Syndrome and cancer.
  • Further research into p57(KIP2) will elucidate its full physiological and pathological significance.